Investigates the impact of thioredoxin system inhibitors in colorectal cancer metastasis

Oxidative stress is elevated in cancer cells due to rapid growth and hypoxia, leading to upregulation of the thioredoxin system, which supports cell survival, proliferation, and metastasis. Targeting the thioredoxin system, especially under hypoxic conditions, shows promise as a therapeutic approach against colorectal cancer. Dr. Nurul Akmaryanti Abdullah, a scientist at the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, is leveraging a colorectal cancer cell line model to study the effects of thioredoxin system inhibitors on colorectal cancer metastasis under hypoxic conditions.

In her research, key protein targets in the thioredoxin and hypoxia pathways were identified, and their expression was evaluated using Western Blot. However, challenges arose, including extended screening times for multiple antibodies, inconsistent Western Blot results, and low-quality images across various runs.

The Jess system offers an exciting solution. As newcomers to this technology, we’re impressed by its potential. This automated Western blot system streamlines the traditional process, significantly reducing the manual, labor-intensive workflow. With Jess, we’re optimistic about improving the efficiency and reliability of our protein expression studies.

"We engaged Biomed Global’s Jess lab service, and the experience has been outstanding. The lab scientist was exceptionally helpful, offering valuable insights into both the technical and theoretical aspects of the process. I am very satisfied with the professionalism and quality of service provided by Biomed Global."